Thursday, March 15, 2012

Difference Maker

Lyman Wood says he still gets solicitation letters from Harvard every year, even though he's never given his alma mater a dime.

It's not that he doesn't have the means to contribute, or that he has any personal issues with the school at which he earned both a bachelor's degree and an MBA nearly 50 years ago. He just doesn't see the point.

"They have a $30 billion endowment ... they don't need my money, while plenty of other people do," said Wood, who told BusinessWest that he doesn't send checks to Cambridge because he has no idea how that money might be used and, more importantly, because no matter where it went, it probably wouldn't make much of an impact on a community …

Southwest Airlines grounds dozens of jets to examine structural soundness

Southwest Airlines Co. canceled flights and temporarily grounded 43 planes to examine if they were sound enough to carry passengers, the latest twist in the low-cost carrier's saga of missed safety inspections and civil penalties.

The groundings on Wednesday affected about 8 percent of Southwest's fleet, and came as the airline faces a $10.2 million (euro6.6 million) civil penalty for continuing to fly nearly 50 planes that hadn't been inspected for cracks in their fuselages.

Southwest shares fell more than 9 percent before closing down 7.3 percent.

Since the Federal Aviation Administration announced the penalty last week, Southwest has endured a …

NHS board position for Bristol nurse

Ruth Brunt, director of nursing at North Bristol NHS Trust, is oneof only two nurses elected to the policy board of the NHS Employers'assembly.

Launched late last year, the assembly is the new employers'organisation for the NHS in England. The policy board, made up of 22members of the assembly, will determine the strategic direction ofNHS employers and decide on policy issues.

Ruth Brunt said: "This is a very exciting role and I am verypleased to be on the policy board. I think my appointment will begood for North Bristol NHS Trust and good for nursing.

"As the representative of a large acute trust employing more than8,000 staff members, it is important to …

Wednesday, March 14, 2012

¿Qué Hacer con Irak?

El sonido de la trompeta no habia sido tan incierto como en el actual debate acerca de la politica inmediata hacia Irak. Ni siquiera durante la fase inicial de la guerra de Vietnam la poblacion se habia enfrentado a tanta incertidumbre y division dentro de los circulos oficiales y en los medios de comunicacion. Hasta el momento de preparar este articulo prevalecia la confusion. Una confrontacion entre "halcones" y "palomas" es demasiado visible como para pasarla por alto.

Por un lado, las "vacas sagradas" de anteriores administraciones republicanas, individuos algo pasados en anos, apoyados aparentemente en la cautela de la Secretaria de Estado. Por el otro, un sector oficialista …

Union files complaint to stop move of NYC Opera

NEW YORK (AP) — A union has filed a federal complaint against the troubled New York City Opera, saying the company's plans to move out of Lincoln Center after 45 years undermines the labor rights of the singers, dancers and stage crew members who work for the company.

The American Guild of Musical Artists says the opera's move to a smaller venue and a shorter schedule will mean less work for union members, who are usually guaranteed a certain number of work weeks per year. It filed a complaint on Thursday with the National Labor Relations Board saying the opera should have negotiated any move with the union.

"They have a legal obligation to bargain and give us all their …

Indian officials dismiss Danish climate proposal

Top Indian officials dismissed a draft climate change proposal by Denmark that expects developing economies to peak their greenhouse gas emissions by 2025, news reports said Monday.

The draft document was circulated to a few countries ahead of the Dec. 7-18 summit in Copenhagen, which is supposed to draw up an agreement for controlling emissions of carbon dioxide and other gases causing global warming.

Environment Minister Jairam Ramesh said the Danish draft was "totally unacceptable," The Economic Times reported.

"We are never going to take on a peaking year for absolute emissions. This is not on the horizon," Ramesh told the …

Ad battle is electrifying

With negotiations set to heat up in Springfield this week onlegislation that would open the electricity market in Illinois tocompetition, backers of competing plans are using radio and newspaperadvertising campaigns in a battle for support.

Commonwealth Edison Co. has been running ads lauding a plan itand Illinois Power Co. back that would bring competition to largeindustrial and commercial customers in the state in 2000 andresidential customers in 2005. The ads say other plans placeconsumers at risk.

"The plan we support was put together by most of the state'selectric utilities and others," says the radio spot. "And it's theonly plan that doesn't risk the …

Huntsman says he'd be open to run as Bachmann's VP

WASHINGTON (AP) — Republican presidential hopeful Jon Huntsman says he'd be open to running as vice president if rival and tea party favorite Michele Bachmann wins the nomination.

The former Utah governor, who was appointed ambassador to China by President Barack Obama, says that every time he's been asked to serve his country he's answered "yes." He resigned his China ambassadorial post earlier this year.

Huntsman told CNN interviewer Piers Morgan on Monday that if asked by the Minnesota congresswoman to run as her vice president he'd "be the first person to sign up, absolutely."

Huntsman tried quickly to backtrack, saying the answer was based on a hypothetical question …

Samurai fever in Japan after World Cup victory

Japan fans have celebrated in big numbers after the national team made rare progress to the second round of the World Cup.

The national team, known as Blue Samurai, beat Denmark 3-1 in its final group game Friday to reach the round of 16 for the first time ever outside …

Top five

TELEVISION

1. "NBA Finals Game 7: Detroit at San Antonio," ABC.

2. "Dancing With the Stars," ABC.

3. "NBA Finals Game 6: Detroit at San Antonio," ABC.

4. "CSI: Crime Scene Investigation," CBS.

5. "Two and a Half Men," CBS.

(From Nielsen Media Research)

FILM

1. "Batman Begins," Warner Bros.

2. "Bewitched," Sony.

3. "Mr. & Mrs. Smith," 20th Century Fox.

4. "Herbie: Fully Loaded," Disney.

5. "George Romero's Land of the Dead," Universal.

(From Exhibitor Relations Co.)

HOT FIVE

1. "We Belong Together," Mariah Carey. Island.

2. "Inside Your Heaven," Bo Bice. RCA.

3. "Inside …

National Basketball Association

W L Pct GB
Boston 13 2 .867 _
Toronto 9 8 .529 5
New Jersey 8 8 .500 5 1/2
New York 5 10 .333 8
Philadelphia 5 11 .313 8 1/2
Southeast Division
W L Pct GB
Orlando 14 4 .778 _
Washington 8 9 .471 5 1/2
Atlanta 6 9 .400 6 1/2

Toyota faces federal, congressional probe

Federal prosecutors have launched a criminal investigation into Toyota Motor Corp.'s safety problems and the Securities and Exchange Commission was probing what the automaker told investors, the company disclosed Monday. Newly released internal documents showed that Toyota officials visited with U.S. regulators years ago who "laughed and rolled their eyes in disbelief" over safety claims.

The twin developments created new public relations challenges for Toyota plus the prospects _ however likely or unlikely _ of hefty federal fines or even indictments against executives in the U.S. and Japan. They also complicate Toyota's ability to discuss details driving …

French Grand Prix Results

LE MANS, France (AP) — Results Sunday from the French Grand Prix at the 4.185-kilometer (2.6-mile) Le Mans circuit (with rider, country, motorcycle and time):

Tuesday, March 13, 2012

Hospital fund-raiser is successful operation

Small wonder the bright young things of the Children's ServiceBoard of Children's Memorial Medical Center were beaming.

When the excitement of their little cocktail party was over,they had more than $20,000 to contribute to the cause.

And that was just for openers. The gathering was merely apreliminary round before the main fund-raising event on Sept. 14.

The board's primary benefit is the $60 per person luncheondoings of the 34th annual Chicago Fashion Award Show in theInternational Ballroom of the Chicago Hilton and Towers.

The secret of the kickoff's success was simple: The entire partywas underwritten by AT&T and Stein & Co. With such financial backing,the board was able to make a clear profit on the $50 per personticket prices plus the money from an array of pricey merchandise soldat silent auction and sundry other items.

About 180 guests turned out at AT&T's new corporate center lobbyin the Loop. The added attraction was the Chicago debut of vogueing,the dance craze from New York.

David Ian, one of New York's hot vogueing masters, came in forthe evening to lead a group ofGus Giordano dancers in the stylizedversion of runway modeling. They wore a series of Gianni Versacefashions as they did their stuff.

The board is a fund-raising auxiliary arm of the Children'sMemorial Medical Center.

Its particular cause is raising money to finance the center'stransport program, a lifesaving arrangement that provides emergencymedical attention and immediate ground and air transportation forcritically ill or injured children.

Sherron steals the show

Out on the court, Bill Self stood on a ladder, trimmed a swatch of net and waited for T. Boone Pickens to make him the richest man in his craft. Under the stands, the Rev. Jesse Jackson sought out Derrick Rose and told him to hold his head high, not difficult when he's the sport's next great point guard and awaits megamillions himself in the NBA.

''Champions don't shed a weakness,'' he said, quoting Jackson.

But on a night of compelling stories, many involving a Midwestern metropolis that had no teams involved in the NCAA tournament, who knew that an injured, somewhat forgotten, 5-11 fireplug of a point guard would trump the celebrated Rose and help Kansas win the national championship? Sherron Collins wasn't the biggest hero, not after Super Mario Chalmers hit the three-pointer at the end of regulation -- we're still waiting for a foul, John Calipari -- that goes down among the biggest shots in college hoops history. Yet he was the Chicago point guard having the fun, pushing the ball, creating the symmetry and, in the end, winning the trophy that was supposed to belong to the Memphis phenom.

Sometimes, a Rose has a thorn. Sometimes, it's a kid like Collins making a big steal, hitting a three-pointer, slashing the lead to four points and giving Kansas a measure of hope, which shouldn't have existed after trailing by nine with just over two minutes left. Sometimes, it's The Other Guy who makes the free throws that Memphis could not, dribbles out the clock in overtime, thrusts his index finger in the air and breaks into a grin after a 75-68 victory.

''Once they let us back in, we knew we were going to take off,'' Collins said. ''That's why we're the national champs.''

Here, it was about Kansas and Memphis in an all-timer. But back home, it's about Collins and Rose. Remember that February night in 2006, when Collins went 2-for-20 from the field but still managed 10 assists for Crane in a 59-57 win over Rose and Simeon? Remember the rematch, when Simeon romped in the Public League quarterfinals? This was Collins ruling Rose again. While Memphis was free-falling in a classic collapse -- confirming its bad rep by missing four of five late free throws, going several minutes without a basket and watching center Joey Dorsey foul out late in regulation -- the cooler team won. You also could say the better coach won, a coach who was smart enough to use Collins more than usual. Now we'll see if Kansas is smart enough to ante up for Self after Oklahoma State, stoked by billionaire benefactor Pickens, offers a reported 10-year, $40-million deal with a $6 million signing bonus.

EVEN SELF IS A LITTLE STUNNED

''I'm a little in shock, a little overwhelmed,'' said Self, who left Illinois for Kansas five years ago and finally has seen his dream job materialize. ''I don't know if a coach deserves to have happen what happened to me tonight. I can't imagine it being any better at any time.''

Oh, I can. When Self makes $1.3 million a year and is being offered $6 million up front, it could be better in Stillwater. We'll see if Kansas understands that he has maximized the basketball religion in Lawrence -- why was his predecessor, Roy Williams, wearing a Jayhawks sticker on his shirt and upsetting the folks in North Carolina? -- and gives Self the elite deal he deserves. They wouldn't want a bittersweet ending after Chalmers made history.

''Yeah, I thought it was going in,'' said Chalmers, colder than his native Alaska in nailing the shot. ''I knew my teammates had confidence in me. I know Coach had confidence in me.''

Only minutes before, Self sensed defeat in the huddle. He was right. ''I thought the game was over,'' Darrell Arthur said. ''Coach called timeout and said, `You've got to believe.' ''

''I didn't think it was over,'' Self said.

And what else did he say? ''He told us to foul a couple of their bad [free-throw] shooters,'' Chalmers said.

In the end, it was Rose who opened the door for Chalmers. He had been shooting well from the line, but he caught his teammates' virus and missed one of two with 10 seconds left. ''When Derrick went to the line, everything in life happens for a reason,'' Calipari said. ''I said, 'Lord, if he makes these two, were supposed to be national champions.' But if he misses them, I'm fine with that, too. I'm probably not supposed to say that religiously.''

THE FUTURE IS STILL ROSE-Y

Rose, whose calf cramped at the end of regulation, was stunned after losing what surely was his final college game. ''I knew it was going to be another war going into overtime. We just couldn't get it done,'' he said. ''When we were at the line, we were trying to make them. I guess we didn't do it. But it wasn't the free throws. It was the [Chalmers] shot.''

Not that Rose can be blamed. Years from now, when he's rich and famous and doing Gummy Bear commercials, we'll remember him for the night when he almost commandeered the big game. Turn on the TV today -- next week, next month, next year -- and you will see two sequences replayed over and over. You will watch him every time, too. On the first play, he takes a pass, hurls his chiseled torso toward the basket against Chalmers and flips in a spectacular layup off the general vicinity of his hip. On the next play, he lifts off by the three-point line, adjusts in mid-air to the outstretched arm of Darnell Jackson and hits the fallaway two-pointer. He scored 10 straight points for in crunch time, 12 in a seven-minute run. But in the frantic final seconds, the Tigers cracked.

Who knew that Kryptonite for Rose, the Superman of the tournament, would come in the form of Collins? Sometimes lost in the glut of talent at Kansas, he has started only six games in two years and has been bothered much of this season by numerous injuries -- stress fracture of his left foot, bruises on both knees, tendinitis in his left knee and ankle sprains. But when Self stuck Collins on Rose only minutes after tipoff.

He didn't make a shot the rest of the first half. Rose also committed three turnovers and didn't have the ball nearly as much as he's accustomed. For the first time since early December, Memphis trailed by five at halftime. As expected, a Chicago story was developing; unexpectedly, the subject wasn't Rose. ''I was never overshadowed by him. I was in front of him by a year,'' Collins said of their respective Public League careers. ''I got all the respect I deserved. He's a good player.''

Unlike Rose, who is looking at $60 million in endorsements and salary once he declares for the NBA draft, Collins isn't bound for the next level just yet. His son, Sherr'mari, turned one Sunday. The boy lives in Chicago with Collins' girlfriend, Re'Quiya Aguirre, who puts the phone up to the baby's era when Sherron calls.

Someday, he'll tell Sherr'mari about the night he beat Derrick Rose for the title.

Photo: Streeter Lecka, Getty Images / Memphis' Derrick Rose and Kansas' Sherron Collins battle for a loose ball Monday night. ;

Modulation of the conductance of unitary cardiac L-type Ca(2+) channels by conditioning voltage and divalent ions

ABSTRACT The accompanying paper (Josephson, I. R., A. Guia, E. G. Lakatta, and M. D. Stern. 2002. Biophys. J. 83:2575-2586) examined the effects of conditioning prepulses on the kinetics of unitary L-type Ca2+ channel currents using Ca2+ and Ba2+ ions to determine the ionic-dependence of gating mechanisms responsible for channel inactivation and facilitation. Here we demonstrate that in addition to alterations in gating kinetics, the conductance of single L-type Ca2+ channels was also dependent on the prior conditioning voltage and permeant ions. All recordings were made in the absence of any Ca2+ channel agonists. Strongly depolarizing prepulses produced an increased frequency of long-duration (mode 2) openings during the test voltage steps. Mode 2 openings also displayed >25% larger single channel current amplitude (at 0 mV) than briefer (but well-resolved) mode 1 openings. The conductance of mode 2 openings was 26 pS for 105 mM Ba2+ 18 pS for 5 mM Ba2+, and 6 pS for 5 mM Ca2+ ions; these values were 70% greater than the conductance of Ca2+ channel openings of all durations (mode 1 and mode 2). Thus, the prepulse-driven shift into mode 2 gating results in a longer-lived Ca2+ channel conformation that, in addition, displays altered permeation properties. These results, and those in the accompanying paper, support the hypothesis that multiple aspects of single L-type Ca2+ channel behavior (gating kinetics, modal transitions, and ion permeation) are interrelated and are modulated by the magnitude of the conditioning depolarization and the nature and concentration of the ions permeating the channel.

INTRODUCTION

Although it has been convenient to conceptualize ion channel gating as a simple two-state system (open and closed), most ligand-gated and voltage-gated ion channels display multiple conductance levels. For L-type Ca2+ channels, multiple conductance levels have been previously reported using cardiac myocytes (Chen and Hess, 1987), neurons (Church and Stanley, 1996), GH3 cells (Kunze and Ritchie, 1990), Ca2+ channel proteins reconstituted in bilayers (Ma and Coronado, 1988), and expressed al subunits of the L-type Ca2+ channel (Gondo et al., 1998; Cloues and Sather, 2000). However, the conditions that may promote a given conductance level remain largely unknown. Moreover, the properties of conductance states may contain important information concerning permeation and gating mechanisms necessary for a further understanding of the structure of the L-type Ca2+ channel.

High-voltage prepulses have been shown to facilitate single Ca2+ channel activity by promoting a mode of Ca2+ channel gating (one that is characterized by openings of unusually long duration, as compared with the briefer, mode 1 openings) using Ba2+ ions (Pietrobon and Hess, 1990; Hirano et al., 1999) or Ca2+ ions as the charge carrier (Josephson et al., 2002). These prepulse-facilitated single Ca2+ channel currents resemble the long-duration (mode 2) type of gating originally described for L-type Ca2+ channels during exposure to dihydropyridine agonists (Hess et al., 1984) or following /beta-adrenergic stimulation (Yue et al., 1990).

However, there is little information available concerning the conductance properties of mode 2 L-type Ca2+ currents, especially those recorded under more physiological conditions; that is, using a low concentration of Ca2+ ions as the charge carrier, and in the absence of L-type Ca2+ channel stimulation or agonists. In the present paper we focus on the conductance of unitary cardiac L-type Ca2+ channel currents displaying long-duration (mode 2) openings. We report that mode 2 L-type Ca2+ channel currents, recorded using Ca2+ and Ba2+ ions, are not only longer in duration, but also of greater conductance than briefer (but fully resolved) mode 1 openings. A preliminary report of some of these results has been presented in abstract form (Josephson et al., 2001c).

Increased conductance of mode 2 openings

To directly evaluate the conductance of mode 2 openings we measured the amplitudes of long-duration mode 2 openings that occurred near the end of a test pulse, and remained open during and after repolarization of the test pulse to the holding potential. The mode 2 single Ca 2+ channel "tail currents" had the advantage of yielding a slope conductance arising from individual, identifiable long-lasting openings of a single channel. As the deactivation of mode 2 is relatively slow, repolarization increases the electrochemical driving force on the permeating ions, and thus increases the single channel current amplitude. Examples of single mode 2 Ca2+ channel tail currents are shown in Fig. 3 A (traces a and b were recorded with 105 mM Ba2+ ions; c and d with 5 mM Ba2+ ions). Accompanying each current trace is the all-points histogram (Fig. 3 B) showing the amplitude of the long opening during the test pulse, and following repolarization. The current amplitudes were measured as the midpoints obtained from Gaussian fits to the all-points histograms.

The voltage-dependence for the amplitudes of single Ca2+ channel currents recorded during mode 2 tail current openings are compared with Ca2+ channel openings of all durations (recorded during single test steps, and identified and analyzed by a 50% threshold method) in Fig. 4. It should be noted that "all openings" included mode 2 openings as well as briefer mode 1 openings; however, the frequency of mode 2 events in the absence of a facilitating prepulse was usually <5% of the total number of openings. Part A displays results using 105 mM Ba2+ ions, part B with 5 mM Ba2+ ions. With 105 mM Ba2+ ions, the slope conductance was 25.7 +/- 1.2 pS for mode 2, whereas a linear regression to the average data for all openings (single steps) gave a slope conductance 14.5 +/- 0.5 pS. For 5 mM Ba2+ the slope conductance was 18.2 +/- 0.6 pS for mode 2, and was 10.8 +/- 0.4 pS for all openings. In addition to these differences in modal conductance, the apparent single channel reversal potentials were also different. For 105 mM Ba2+ ions, the extrapolated apparent reversal potential was +47 mV for mode 2 openings versus +65 mV for all openings; for 5 mM Ba2+ the extrapolated apparent reversal potential was +32 mV for mode 2 versus +38 mV for all openings.

As mode 2 tail current measurements were extremely rare with 5 mM Ca2+ ions (due to decreased frequency of reopenings near the end of the test step), mode 2 openings were measured during single voltage steps by the all-points amplitude histogram method, as shown in Fig. 5. Part A displays examples of mode 2 openings occurring during single voltage steps to the test potentials indicated. Part B shows the corresponding all-points histograms, constructed using segments of the traces surrounding the openings (as indicated by the arrows). The all-points histograms were fit with a sum of Gaussian functions to obtain the average amplitude of the mode 2 opening. With 5 mM Ca 2+ ions, a linear regression to the average amplitude data gave a slope conductance of 6.1 +/- 0.3 pS for mode 2, and 3.6 +/- 0.2 pS for openings of all durations (Fig. 5 Q. The extrapolated apparent reversal potential for 5 mM Ca2+ was + 32 mV for mode 2 versus +60 mV for openings of all durations.

Thus, with Ca2+ ions and Ba2+ ions, facilitation by high-voltage prepulses produced longer-duration mode 2 openings that attained a significantly greater conductance than shorter-duration (but fully resolved) openings. The implications of this novel voltage-dependent change in Ca2+ channel permeation (and gating kinetics) will be discussed subsequently.

DISCUSSION

The results of this paper and the accompanying paper (Josephson et al., 2002), demonstrate that multiple aspects of single L-type Ca2+ channel behavior (gating kinetics, modal transitions, and single channel conductance) are influenced by the magnitude of the conditioning depolarization and the nature and concentration of the permeant ion. A novel and important feature of the present results is the demonstration that strong depolarization not only resulted in a shift to mode 2 long-openings using a low concentration of Ca2+ ions, but also tended to temporarily "lock" the Ca2+ channel in its highest conductance conformation.

Similarly, an early report on L-type Ca2+ channels in smooth muscle cells (Caffrey et al., 1986) demonstrated that BayK8644, a Ca2+ channel agonist that pharmacologically promotes mode 2 long openings, also increased the single Ca2+ channel conductance by 25% (from 12 pS to 15 pS using 100 mM Ba2+ ions), and an increase in single channel current amplitude with CPG (another DHP derivative that also promotes mode 2) has been reported for cardiac L-type Ca2+ channels (Kokubun and Reuter, 1984). We have also found that another Ca2+ channel agonist, FPL 64176, increases the single channel conductance to the same level as that of mode 2 openings (Josephson, personal observation).

The conductance of single cardiac L-type Ca2+ channels has been reported over a wide range of values in previous studies, even in the absence of agonists and using the same divalent ion concentration (see Guia et al., 2001, for a review of the literature). In light of the present results, it seems plausible that contributing to at least a part of this range may be the variable number of mode 2 openings (as compared with mode 1) recorded in previous studies. The frequency of mode 2 openings (in the absence of voltagefacilitation or agonists) may be related to many factors, including species differences, endogenous intracellular levels of cyclic AMP or other second messengers, and the metabolic state of the myocytes. Moreover, mode 2 openings (that attain a stable amplitude level for an extended period of time) may have been favored in those previous studies where Ca2+ channel amplitude was measured by hand, thereby yielding a higher estimate of conductance.

In the present study mode 2 Ca2+ channel openings not only displayed a larger slope conductance but, in addition, the extrapolations of their slope conductances to the zero current level gave apparent reversal potentials that were less positive than those obtained from the conductance measurements obtained from all openings. This finding raises the intriguing possibility that during mode 2 the Ca 21 channel is temporarily less selective for divalent cations (i.e., Ca2+ and Ba2+), and that monovalent cations having a less positive reversal potential (such as cesium ions in our experiments, or sodium ions physiologically) may be allowed to permeate the channel. To speculate further, this loss of selectivity may be facilitated by high-voltage prepulses that might have the effect of driving divalent cations (i.e., Ca2+ ions) from their extracellular binding sites (perhaps in the pore region) that normally confer the divalent Ca2+ ion selectivity to the Ca2+ channel. Further experimentation using a variety of ionic conditions will be needed to test this novel hypothesis.

Physiological relevance

A voltage- and time-dependent switch promoting a mode 2 behavior of the Ca2+ channel would be a rapid and powerful mechanism to greatly enhance Ca2+ influx during an ongoing train of cardiac action potentials (activity-dependent potentiation). With a 10- to 100-fold increase in mean open time (Josephson et al., 2002) and a 70% increase in conductance, this facilitory mechanism may have a profound effect on the local control of excitation-contraction coupling (see Stem, 1992), whether in directly producing Ca2+induced Ca2+ release from the sarcoplasmic reticulum (SR) or in refilling the SR subsequent to Ca2+ release.

Even in the absence of activity-dependent potentiation, voltage-induced long openings might play an important role during individual action potentials. The plateau phase of the cardiac ventricular action potential (of most mammalian species besides rat and mouse) remains relatively constant for >100 ms at positive potentials. With a physiological Ca2+ ion concentration (1.8 mM) the voltage-dependence for activation of mode 2 would be shifted to less positive potentials, thus at plateau potentials long openings may be activated in a substantial number of Ca2+ channels. As the deactivation of mode 2 is relatively slow compared to the briefer mode 1 gating (especially at depolarized potentials), mode 2 openings would also be occurring during the repolarization phase of the action potential. In addition, as repolarization progresses the driving force for Ca2+ ion entry would also increase. The result of these factors would be a much larger influx of Ca2+ ion during the later phases of the action potential than would otherwise occur in the absence of this facilitory mechanism.

Facilitation of Ca2+ influx could also be potentiated by this voltage- and time-dependent mechanism in rat and mouse heart because in those species the high heart rate would activate mode 2 openings by summation over time, despite the very brief duration of each cardiac ventricular action potential. Thus, a late Ca2+ influx would occur during the repolarization phase of the action potential due to the relatively slow rate of deactivation of the mode 2 openings. Along the same lines, an enhanced Ca2+ influx produced by an augmentation of mode 2 activity during the abnormally rapid-firing, brief action potentials associated with ventricular fibrillation may contribute to Ca2+ overload and further myocardial damage. In addition, frequencydependent enhancement of mode 2 openings may have a role in modulating the activity of the sino-atrial nodal cells.

It also remains to be determined whether L-type Ca2+ channels that are capable of displaying this facilitory behavior may be anatomically localized (with respect to the Ca2+ release channels or other structures of the SR) to take functional advantage of this feature (e.g., in releasing Ca2+ ions, or in refilling the SR). Finally, although the most studied functions of the L-type Ca2+ current are in the electrogenesis of the cardiac action potential and in E-C coupling, we may also speculate that this voltage-dependent facilitation via mode 2 Ca2+ channel openings is involved in other Ca 2+-dependent signaling functions, such as activation of gene expression, or apoptosis.

In conclusion, the present results (which were obtained in the absence of any Ca2+ channel agonists and using a low concentration of Ca2+ ions and Ba2+ ions) demonstrate that strong depolarization drives the native cardiac L-type Ca2+ channel into a conformation that enables larger-amplitude, longer-duration openings. These findings suggest an intimate relationship of the voltage-sensing regions with the permeation-determining regions of the Ca2+ channel. It will be of great importance to gain a further understanding of the properties of these long openings as they undoubtedly play a important role in the local control of E-C coupling (Stem, 1992) in normal, aging, and diseased hearts.

The authors thank Bruce Ziman for excellent preparation of the isolated myocytes.

[Reference]

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[Reference]

Stem, M. D. 1992. Theory of local control of cardiac excitation-contraction coupling. Biophys. J. 63:497-517.

Yue, D., S. Herzig, and E. Marban. 1990. B-adrenergic stimulation of Ca" channels occurs by potentiation of high-activity gating modes. Proc. Natl. Acad. Sci. U.S.A. 87:753-757.

[Author Affiliation]

Ira R. Josephson, Antonio Guia, Edward G. Lakatta, and Michael D. Stern

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 USA

[Author Affiliation]

Submitted February 27, 2002, and accepted for publication June 3, 2002.

[Author Affiliation]

Address reprint requests to Dr. Ira Josephson, Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224. Tel.: 410-558-8644; Fax: 410-558-8150; E-mail: josephsoni@grc.nia.nih.gov.

Ford to delay introduction of new F-150 pickup due to sagging sales, need to reduce inventory

Ford Motor Co. says it will delay introduction of its new F-150 pickup truck by two months because of the declining market for the vehicles.

The company also said Friday it expects industrywide U.S. sales this year to drop to a range of 14.7 million and 15.2 million units. The company previously had predicted 15 million to 15.4 million units.

Because of that, Ford says it will cut third-quarter production by another 50,000 vehicles. It now plans to produce 475,000 vehicles, 25 percent fewer than the third quarter of last year.

The company also says fourth-quarter production will drop 8 to 14 percent compared with the same quarter last year.

McCain aide says he's strong in 'real' Virginia

A top aide to John McCain said Saturday the Republican presidential nominee still has a strong chance of winning the state because of his support in "real Virginia," the downstate areas far removed in distance and political philosophy from the more liberal northern part of the state.

"As a proud resident of Oakton, Va., I can tell you that the Democrats have just come in from the District of Columbia and moved into northern Virginia," McCain senior adviser Nancy Pfotenhauer said on MSNBC. "And that's really what you see there. But the rest of the state, real Virginia, if you will, I think will be very responsive to Sen. McCain's message."

Program host Kevin Corke asked Pfotenhauer if she wanted to retract the comment, prompting her to reply, "I mean 'real Virginia' because northern Virginia is where I've always been, but 'real Virginia' I take to be the _ this part of the state that is more Southern in nature, if you will. Northern Virginia is really metro D.C."

Earlier this month, McCain's brother, Joe, told those at an event for the Republican nominee that two Democratic-leaning areas in Northern Virginia, Arlington and Alexandria, were "communist country." He quickly apologized and called the remark a joke.

The senator's campaign headquarters is in Arlington, as is the home he uses while in Washington. McCain also attended high school in Alexandria.

Northern Virginia is the most populous in the state, so if McCain considers it enemy territory, he would have to run up large margins in the Hampton Roads and less populated areas of Virginia to win on Election Day. During a rally in the Washington suburb of Woodbridge, Va., on Saturday, McCain noted that his first posting in the Navy was in coastal Norfolk.

Democrats not only control the Virginia governor's office, but Democrat Jim Webb succeeded in 2006 in ousting Republican Sen. George Allen. Veteran Sen. John Warner, R-Va., is retiring this year and former Democratic Gov. Mark Warner is vying with former Republican Gov. Jim Gilmore to succeed him.

The popularity of Mark Warner has led some to suggest he may boost Democrat Barack Obama's chances, rather than the opposite.

One recent poll showed McCain trailing Obama by up to 8 percentage points in the Old Dominion, but political analysts believe the race may be closer. McCain was making a push to hold onto Virginia, which President Bush won in 2004.

Besides his rally in Woodbridge, McCain's campaign was launching a downstate bus tour on Sunday with Todd Palin, the husband of his running mate, Alaska Gov. Sarah Palin.

One of those attending McCain's rally said she wasn't sure about the geographical split of the state.

"I just hope that the state of Virginia will continue to support and continue to be a red state," said 45-year-old Diane Fuller of Manassas.

___

On the Net:

McCain campaign: http://www.johnmccain.com/

Obama campaign: http://www.barackobama.com/index.php

Smartphone app lets workers track wages

WASHINGTON (AP) — Workers who don't trust the boss to keep track of their wages can now do it themselves with a new smartphone application from the Department of Labor. But employers worry that the time sheet app, along with other new initiatives, could encourage even more wage and hour lawsuits.

The app, called DOL-Timesheet, lets workers calculate regular work hours, break time and overtime pay to create their own wage records. Department officials say the information could prove valuable in a dispute over pay or during a government investigation when an employer has failed to keep accurate records.

"This app will help empower workers to understand and stand up for their rights when employers have denied their hard-earned pay," Labor Secretary Hilda Solis said.

The app is the latest example of the Obama administration's push for more aggressive enforcement of wage and hour laws. The agency has hired about 300 more investigators to probe complaints of unpaid work time, lack of overtime pay and minimum wage violations.

Last year, the agency began a "Bridge to Justice" program that, for the first time, helps connect aggrieved workers with private lawyers if the department's Wage and Hour Division is too busy to handle a complaint.

As a result, legal experts say, wage and hour compliance has become a leading concern for employers as the new policies help drive up litigation over unpaid wages, also known as wage theft.

"The government is focusing on it like never before," said Gerald Maatman, an employer-side labor lawyer based in Chicago. "I think the mantra is kind of, 'All enforcement, all the time, 24/7.'"

Workers brought a record number of wage and hour suits against employers last year, according to an analysis of court filings by Maatman's firm, Seyfarth Shaw. Nearly 6,800 such suits were filed in 2010, about 700 more than the previous year. Most were collective or class actions.

"The concern is that the Department of Labor is putting a lot more attention into this area and employers, at the same time, are putting more hours, more money and more work into auditing and complying with wage and hour laws," Maatman said. "It's turning into somewhat of a full-time job."

The stepped up enforcement is a change from the Bush administration, when some critics accused President George W. Bush's labor secretary, Elaine Chao, of favoring businesses and weakening job safety and enforcement efforts.

While employers are not surprised about increased enforcement, they have questioned some tactics, such as a program that gives workers a toll-free number to contact an attorney referral service run by the American Bar Association.

The Wage and Hour Division gets more than 35,000 calls a year for help and doesn't have the resources to deal with every claim. For those it can't help, it now refers them to the toll-free hot line, where they can be referred to a lawyer who specializes in wage and hour disputes.

Michael Kun, a management-side employment lawyer in Los Angeles, calls the program "a gift to plaintiff's lawyers."

"A DOL investigator has no incentive to pursue a meritless claim," Kun said. "A plaintiff's lawyer has some incentive to do that to get some sort of nuisance value."

Patricia Smith, the Labor Department's top lawyer, says the criticism has taken her by surprise. Before the Bridge to Justice program, the department simply told workers they had a private right of action.

"This just gives them a little more information if they want to exercise it, to go to an attorney that's qualified, as opposed to calling the guy who has advertisements on television at midnight," Smith said.

Nancy Leppink, who heads the Wage and Hour Division, says the office is just doing the job it's supposed to do, which is going after employers who cheat workers out of their hard-earned wages.

"To the extent we have employers who are not complying with the law, we have an obligation to look for all of the opportunities we can to change that behavior," Leppink said.

That includes the department's "We can help" advertising campaign last year, designed to educate employees in the food service, hospitality, apparel, manufacturing and construction industries about their legal rights under federal wage and hour laws.

Wage theft is especially prevalent among immigrant workers who don't speak English or hesitate to challenge their boss for fear of jeopardizing immigration status, labor officials say.

Earlier this year, for example, the department recovered $1.8 million in back wages for nearly 400 workers at the Houston-based Hong Kong Market grocery chain. Investigators found some employees worked as many as 70 hours a week, but were paid less than the minimum wage and denied overtime pay. Labor officials said the company deliberately misled investigators by falsifying payroll records.

The new smart phone app is expected to help low wage immigrant workers, many of whom can't afford a computer, but keep cell phones as a lifeline to family back home.

The app is currently available for the iPhone and iPod Touch, but the agency is exploring versions for use on other devices, including Blackberry and Android smartphones.

___

Online:

Labor Department's Hour and Wage Division: http://www.dol.gov/whd/

Seyfarth Shaw law firm: http://www.wagehourlitigation.com/

UN rights chief notes Russia's setbacks on rights

MOSCOW (AP) — The U.N's top human rights official on Thursday decried violence in Russia against activists and journalists but said the country has made some incremental moves toward reform.

U.N. High Commissioner for Human Rights Navi Pillay said her four days of meetings with Russian officials, including President Dmitry Medvedev, show there is "some recognition at the top" that Russia's observance of human rights is seriously flawed.

"I commend the president for his clear vision and public statements concerning the importance of such reforms," she said at a news conference. "There has undoubtedly been some progress, but also some setbacks — including murders, intimidation and harassment of human rights defenders and investigative journalists and independent media, and apparent serious miscarriages of justice."

Reforms under Medvedev "have not advanced sufficiently to be considered a success," she said.

Pillay drew attention to the case of Alexei Sokolov, a rights activist who had campaigned against torture and corruption in law enforcement agencies and who was sentenced to five years imprisonment last year on charges of theft. She called for an independent investigation to be launched.

Pillay also cited problems were particularly acute in Russia's Caucasus region, where rights violations appear to be fueling an Islamist insurgency.

Answering call for gifts that scream 'Chicago'

Quite a number of readers answered my plea for unique Chicago gift ideas for out-of-town friends, or as

I put it: something that shouts, "I live in Chicago, and you don't."

As much as I appreciate all the suggestions, I'm afraid most only prove my larger point, that it's more and more difficult to buy anything special from here that you couldn't just as easily get there, wherever there happens to be.

I suppose I could give my friend a bag of Chicago street salt or a transcript from one of our political corruption trials, as a few readers suggested. It's true that nothing says Chicago quite like the cross-examination of one of our public officials. But if I were looking to provide that sort of holiday reminder of Chicago Christmases past, I could have just palmed him a C-note.

Still, there were worthwhile suggestions that might help some of you with last-minute shopping, even if they don't prove to be of much use to me.

"My vote for a Chicago-centric gift would be any book from Lake Claremont Press (www.lakeclaremont.com.). They have wonderful books on Chicago history. Where else can you get a title like From Lumber Hookers to the Hooligan Fleet: A Treasury of Chicago Maritime History or The Streets and San Man's Guide to Chicago Eats? As its Web site says, "Lake Claremont Press fosters and celebrates what's distinctive about Chicago's history, culture, geography, spirit and lore." I'm biased because Lake Claremont published my book on the history of Midway Airport." -- Christopher Lynch, West Rogers Park

HOT IDEAS WITH FIRE DEPT. THEME

Sure, Christopher has a conflict of interest, but in Chicago we believe that's permissible if the conflict is disclosed. My own bias is that I keep The Streets and San Man's Guide handy in the car at all times for lunchtime opportunities, although author Dennis Foley should consider updating his 2004 original.

"May I suggest you consider purchasing a Chicago Fire Department poster entitled "These Are The Houses That Courage Built." The poster portrays the images of 100 patches designed by and representing various individual Chicago firehouses and CFD specialty units, as well as the CFD Gold Badge Society. The unframed poster sells for $10 plus shipping and handling. Proceeds benefit the Gold Badge Society, which is comprised of duty-death families of the Chicago Fire Department. For more information, please contact cfdgoldbadge@aol.com.

"My next suggestion would be a miniature version of an authentic Chicago Fire Truck offered by Code 3 Collections. This truck is an exact replica of the fire truck housed at the Chicago Fire Academy and is duplicated to every last detail, including the inscription on the cab door which reads "In Memory of firefighter Steven McNamee." It's called the 1/64 Chicago, IL Pierce Rear Mount Ladder and should still be available for purchase at area police and fire specialty stores." -- MaryRose McNamee

Nifty idea. More disclosure: MaryRose is the widow of Steven, who died in a training accident at the Fire Academy. Steven was a brother of Sun-Times editorial page editor Tom McNamee.

"My husband and I moved here from Ohio 11 years ago. This year we are sending a Breakfast Basket from Dinkel's Bakery, here in Chicago since 1922." --Eleanore Plewacki

I forget about Dinkel's and its "old-fashioned European baking tradition." Shame on me. Find them at 3329 N. Lincoln Ave. and www.dinkels.com.

"I can tell you that 1-800-LOU-TO-GO for Lou Malnati's Pizza is great. I have sent a pizza to a friend in Las Vegas, and it is absolutely great . . . for people that do not live in Chicago and cannot get Chicago-style pizza." -- Ron Weiner, Skokie

While experience makes me leery of frozen Chicago-style pizzas, I can't say I've ever tried this particular approach. If it works, it's certainly a true "eat your heart out" gift.

"I have a great deal of pride in our city and its history. Therefore, this year I will be giving all of my friends and family members The Chicago Bar, a locally made, organic soap bar made in the image and red-white-and-blue colors of the Chicago city flag. It comes from a local company called Ethically Engineered (www.ethicallyengineered.com) that bikes its products to its retailers." -- A. Pierce

That's unique all right, but I'd be careful about giving a friend a bar of soap as a gift lest they get the wrong idea, especially if you've got the sniffles.

Monday, March 12, 2012

EUROPE NEWS AT 0600GMT

UPCOMING COVERAGE FOR TUESDAY, JULY 15:

EU-AGRICULTURE

BRUSSELS _ EU agriculture ministers meet; expected to discuss rising world food prices.

GERMANY-UN

BERLIN _ U.N. Secretary-General Ban Ki-moon meets German Chancellor Angela Merkel. News conference scheduled for 1445GMT.

RUSSIA-DOOMSDAY CULT

MOSCOW _ The leader of the doomsday cult whose members stayed underground in a cave for half a year awaiting the end of the world, goes on trial on charges of setting up a religious organization associated with violence.

GERMANY-ALLAWI PLOT

STUTTGART, Germany _ Verdict expected in trial of three Iraqi men accused of conspiring to kill former Iraqi Prime Minister Ayad Allawi during a visit to Germany in 2004. Court session starts at 0730GMT.

GERMANY-ECONOMY

FRANKFURT, Germany _ ZEW institute releases monthly survey of investor confidence in Germany, a closely watched indicator for Europe's biggest economy. 0900GMT.

The AP

Oil falls again, nears $80 a barrel

Oil prices continued to fall Wednesday as investors remain concerned about the stability of Europe's economy and a possible slowdown to growth in China.

Here's how energy contracts traded.

On the New York Mercantile Exchange:

Crude fell $1.90 to settle at $80.44 per barrel.

Gasoline rose 0.22 cent to settle at $2.1579 a gallon.

Heating oil fell up 5.71 cents to settle at $2.2519 a gallon.

Natural gas added 21.2 cents, or 5.6 percent, to settle at $4.030 per 1,000 cubic feet.

On the ICE futures exchange:

Brent crude dropped $1 to settle at $83.28 per barrel.

3 Mega Millions tickets hit jackpot

Lottery officials say three Mega Millions tickets matched all six numbers and will split the estimated $225 million jackpot.

The tickets were sold in Virginia, Ohio and California and matched the winning numbers drawn Friday night. The winning tickets are now each worth an estimated $75 million.

The numbers drawn Friday were 9-16-24-40-43 and the Mega Ball was 35.

The next Mega Millions drawing, Tuesday night, has a jackpot of $12 million.

Summary Box: Corn falls on crop report

CORN, HUSKED: Corn prices fell again Friday but held up better than the day before. That's when the U.S.D.A reported that U.S. farmers had planted far more acres with the crop than analysts expected.

SEEING SUPPORT: Corn fell as much as 45 cents, the maximum one-day move currently allowed for the December contract, but recovered to settle down 23.75 cents at $5.9675 a bushel.

RECENT RECORD: Corn reached a record high of $7.99 June 10 and has been falling steadily since then. The high price has motivated farmers to plant more acres with the grain at the expense of soybeans.

YouTube video shows NYC officer shoving cyclist

Police have stripped a New York City officer of his badge and gun after a video posted on YouTube showed him body-checking a bicyclist who was part of a Times Square demonstration.

Witnesses say the video was recorded Friday at the Critical Mass ride, a monthly protest of urban reliance on vehicles.

The video, posted anonymously, shows the officer standing in the street as bikes whiz past. He moves toward a cyclist and violently knocks him to the ground in front of crowds of people.

Police have placed the officer on desk duty pending the outcome of a department investigation. His identity wasn't released.

Wilma F. Goldberg; formerly ran S. Chicago retail site

Wilma F. Goldberg, owner and manager of the Henrietta Building inSouth Chicago, died Sunday in Skokie.

She was a member of the first Jewish family to settle in SouthChicago, where her grandfather founded the first South Chicagosynagogue, Bikur Cholim.

Mrs. Goldberg inherited the Henrietta Building, a retail andprofessional building, from her father, and ran it from the mid-1950s to the late 1960s.

She was active in B'nai Brith Women, and a former president of theSouth Chicago B'nai Brith Chapter.

Survivors include two sons, Rabbi Bruce Goldberg and Dr. EugeneGoldberg, as well as three grandchildren.

Services were Tuesday.

Wednesday, March 7, 2012

Kiplagat, Lel Win Peachtree Race

ATLANTA - Lornah Kiplagat of the Netherlands won her fifth Peachtree Road Race title Tuesday and Martin Lel of Kenya captured the men's division to lead a field of 55,000 runners, the world's largest 10-kilometer road race

On a smoggy Fourth of July morning, Lel sprinted away from the lead group of five runners in the fourth mile of the 6.2-mile run and won unofficially in 27 minutes, 20 seconds. With less than a half mile left, Kiplagat made a quick burst to overtake Jemima Jelagat of Kenya and win in 31:09. Kiplagat moved to the Netherlands from Kenya in 2003.

South Africa's Krige Schabort won the men's wheelchair race to add to his 2002 and 2003 titles. Switzerland's Edith Hunkeler took the women's wheelchair division for the second straight year.

The race began at 7:30 a.m. in 75-degree heat on a humid day, with giant American flags flying over the starting line. Many runners wore shorts decorated with the stars and stripes and others carried flags.

Runners Greg Lohman and son Austin of Jacksonville, Fla., painted themselves in the colors of the flag - Greg in stars and Austin, just back from Air Force boot camp, in stripes.

Kiplagat, Lel Win Peachtree Race

ATLANTA - Lornah Kiplagat of the Netherlands won her fifth Peachtree Road Race title Tuesday and Martin Lel of Kenya captured the men's division to lead a field of 55,000 runners, the world's largest 10-kilometer road race

On a smoggy Fourth of July morning, Lel sprinted away from the lead group of five runners in the fourth mile of the 6.2-mile run and won unofficially in 27 minutes, 20 seconds. With less than a half mile left, Kiplagat made a quick burst to overtake Jemima Jelagat of Kenya and win in 31:09. Kiplagat moved to the Netherlands from Kenya in 2003.

South Africa's Krige Schabort won the men's wheelchair race to add to his 2002 and 2003 titles. Switzerland's Edith Hunkeler took the women's wheelchair division for the second straight year.

The race began at 7:30 a.m. in 75-degree heat on a humid day, with giant American flags flying over the starting line. Many runners wore shorts decorated with the stars and stripes and others carried flags.

Runners Greg Lohman and son Austin of Jacksonville, Fla., painted themselves in the colors of the flag - Greg in stars and Austin, just back from Air Force boot camp, in stripes.

Federal panel seeks NWA talks; Mediators brought the airline and its flight attendants together in the hope that the sides can reach a concessionary deal.(BUSINESS)

Byline: Liz Fedor; Staff Writer

The National Mediation Board (NMB) brought Northwest Airlines and its flight attendants union together Monday to discuss the status of their labor dispute, but no formal negotiations were scheduled.

Federal mediators spoke with the two sides during a teleconference. "While details of the discussion are confidential, the NMB remains active in helping the parties reach a consensual labor agreement," the federal board said in a prepared statement.

The flight attendants have rejected two tentative deals so far, although threats of a job action have been set aside temporarily as the airline and passengers cope with new luggage and screening restrictions imposed after a terror plot surfaced last week. Separately, Northwest moved ahead with implementing the new ground workers contract, which includes outsourcing work in small stations to vendors.

The carrier plans to contract with several companies to do ground handling work, including regional partners Mesaba Airlines and Pinnacle Airlines, Northwest spokesman Roman Blahoski said, with the shift to vendors coming this fall and winter. It's been two weeks since flight attendants rejected a tentative agreement that would have saved Northwest about $195 million a year. After the airline imposed work terms on the attendants, leaders of the Association of Flight Attendants (AFA) threatened to begin sporadic strikes as early as today. But the union's executive council decided Friday to delay any job actions until at least Aug. 25 because of the alleged terror plot in Britain.

"Flight attendants who have viewed the delay from a strategic point of view tend to understand the significance of doing that," Danny Campbell, interim vice president of the Northwest branch of AFA, said Monday. But Campbell said many attendants remain "very angry about the injustice they feel" about working under imposed terms and the depth of Northwest's concessionary demands.

A wait-and-see opportunity

Yet the AFA decision to postpone any strike activity had an immediate practical impact. U.S. Bankruptcy Judge Allan Gropper has not issued a ruling concerning Northwest's motion to block a strike by attendants. With the new strike deadline an extra 10 days away, Gropper can wait to see whether the two sides can get back together again.

"We are open to meeting with the AFA to reach a consensual agreement that meets the $195 million [annual] labor savings target for the flight attendants," airline spokesman Bill Mellon said Monday.

Because Northwest is adhering to that concessionary target, Campbell said, "There is not a lot of maneuvering that we can do."

Although talks have not been restarted, Campbell said the two sides met face-to-face Monday afternoon in Bloomington.

The AFA was elected in early July to represent Northwest attendants, so the purpose of the session with airline management was to discuss several administrative matters, Campbell said.

Northwest has ratified agreements with five of its seven unions. The carrier set work terms for flight attendants July 31, while replacement mechanics have been working under imposed pay rates and work rules since last August. Today, Northwest has its first bargaining session of the year scheduled with the Aircraft Mechanics Fraternal Association.

Outsourcing at small stations

The airline's largest union, the International Association of Machinists and Aerospace Workers (IAM), ratified an agreement that allows Northwest to hire outside companies to do work at the stations that have the smallest number of flights.

Northwest's Blahoski said that 69 stations will be affected by the transition to outside contractors. Northwest employees in those cities are expected to use their seniority to transfer to the airline's larger locations, resign, retire or seek employment with the new vendors.

In addition to contracting with Mesaba and Pinnacle for some of the ground handling work, Blahoski said Northwest also plans to use a number of other vendors. He cited Swissport, a large company that does some Northwest maintenance work; regional carrier Air Wisconsin; Worldwide Flight Services; and Airport Terminal Services.

Northwest has begun to circulate a 161-page ground operations restructuring manual for employees but has received some worker criticism about two pages that included 101 ways to save money.

Blahoski said that part of the manual contained suggestions from an outside company. "We agree that some of that material was insensitive," he said, so it will be removed from future manuals. The early version of the manual, which explains retirement benefits, severance payments and bidding rules, was distributed to about 50 employees, mainly at North Dakota stations, he said.

According to the IAM contract, Northwest is prohibited from outsourcing ground handling work at stations that had 50 or more passenger departures a week on the 2005 schedules.

Liz Fedor - 612-673-7709

Federal panel seeks NWA talks; Mediators brought the airline and its flight attendants together in the hope that the sides can reach a concessionary deal.(BUSINESS)

Byline: Liz Fedor; Staff Writer

The National Mediation Board (NMB) brought Northwest Airlines and its flight attendants union together Monday to discuss the status of their labor dispute, but no formal negotiations were scheduled.

Federal mediators spoke with the two sides during a teleconference. "While details of the discussion are confidential, the NMB remains active in helping the parties reach a consensual labor agreement," the federal board said in a prepared statement.

The flight attendants have rejected two tentative deals so far, although threats of a job action have been set aside temporarily as the airline and passengers cope with new luggage and screening restrictions imposed after a terror plot surfaced last week. Separately, Northwest moved ahead with implementing the new ground workers contract, which includes outsourcing work in small stations to vendors.

The carrier plans to contract with several companies to do ground handling work, including regional partners Mesaba Airlines and Pinnacle Airlines, Northwest spokesman Roman Blahoski said, with the shift to vendors coming this fall and winter. It's been two weeks since flight attendants rejected a tentative agreement that would have saved Northwest about $195 million a year. After the airline imposed work terms on the attendants, leaders of the Association of Flight Attendants (AFA) threatened to begin sporadic strikes as early as today. But the union's executive council decided Friday to delay any job actions until at least Aug. 25 because of the alleged terror plot in Britain.

"Flight attendants who have viewed the delay from a strategic point of view tend to understand the significance of doing that," Danny Campbell, interim vice president of the Northwest branch of AFA, said Monday. But Campbell said many attendants remain "very angry about the injustice they feel" about working under imposed terms and the depth of Northwest's concessionary demands.

A wait-and-see opportunity

Yet the AFA decision to postpone any strike activity had an immediate practical impact. U.S. Bankruptcy Judge Allan Gropper has not issued a ruling concerning Northwest's motion to block a strike by attendants. With the new strike deadline an extra 10 days away, Gropper can wait to see whether the two sides can get back together again.

"We are open to meeting with the AFA to reach a consensual agreement that meets the $195 million [annual] labor savings target for the flight attendants," airline spokesman Bill Mellon said Monday.

Because Northwest is adhering to that concessionary target, Campbell said, "There is not a lot of maneuvering that we can do."

Although talks have not been restarted, Campbell said the two sides met face-to-face Monday afternoon in Bloomington.

The AFA was elected in early July to represent Northwest attendants, so the purpose of the session with airline management was to discuss several administrative matters, Campbell said.

Northwest has ratified agreements with five of its seven unions. The carrier set work terms for flight attendants July 31, while replacement mechanics have been working under imposed pay rates and work rules since last August. Today, Northwest has its first bargaining session of the year scheduled with the Aircraft Mechanics Fraternal Association.

Outsourcing at small stations

The airline's largest union, the International Association of Machinists and Aerospace Workers (IAM), ratified an agreement that allows Northwest to hire outside companies to do work at the stations that have the smallest number of flights.

Northwest's Blahoski said that 69 stations will be affected by the transition to outside contractors. Northwest employees in those cities are expected to use their seniority to transfer to the airline's larger locations, resign, retire or seek employment with the new vendors.

In addition to contracting with Mesaba and Pinnacle for some of the ground handling work, Blahoski said Northwest also plans to use a number of other vendors. He cited Swissport, a large company that does some Northwest maintenance work; regional carrier Air Wisconsin; Worldwide Flight Services; and Airport Terminal Services.

Northwest has begun to circulate a 161-page ground operations restructuring manual for employees but has received some worker criticism about two pages that included 101 ways to save money.

Blahoski said that part of the manual contained suggestions from an outside company. "We agree that some of that material was insensitive," he said, so it will be removed from future manuals. The early version of the manual, which explains retirement benefits, severance payments and bidding rules, was distributed to about 50 employees, mainly at North Dakota stations, he said.

According to the IAM contract, Northwest is prohibited from outsourcing ground handling work at stations that had 50 or more passenger departures a week on the 2005 schedules.

Liz Fedor - 612-673-7709

Federal panel seeks NWA talks; Mediators brought the airline and its flight attendants together in the hope that the sides can reach a concessionary deal.(BUSINESS)

Byline: Liz Fedor; Staff Writer

The National Mediation Board (NMB) brought Northwest Airlines and its flight attendants union together Monday to discuss the status of their labor dispute, but no formal negotiations were scheduled.

Federal mediators spoke with the two sides during a teleconference. "While details of the discussion are confidential, the NMB remains active in helping the parties reach a consensual labor agreement," the federal board said in a prepared statement.

The flight attendants have rejected two tentative deals so far, although threats of a job action have been set aside temporarily as the airline and passengers cope with new luggage and screening restrictions imposed after a terror plot surfaced last week. Separately, Northwest moved ahead with implementing the new ground workers contract, which includes outsourcing work in small stations to vendors.

The carrier plans to contract with several companies to do ground handling work, including regional partners Mesaba Airlines and Pinnacle Airlines, Northwest spokesman Roman Blahoski said, with the shift to vendors coming this fall and winter. It's been two weeks since flight attendants rejected a tentative agreement that would have saved Northwest about $195 million a year. After the airline imposed work terms on the attendants, leaders of the Association of Flight Attendants (AFA) threatened to begin sporadic strikes as early as today. But the union's executive council decided Friday to delay any job actions until at least Aug. 25 because of the alleged terror plot in Britain.

"Flight attendants who have viewed the delay from a strategic point of view tend to understand the significance of doing that," Danny Campbell, interim vice president of the Northwest branch of AFA, said Monday. But Campbell said many attendants remain "very angry about the injustice they feel" about working under imposed terms and the depth of Northwest's concessionary demands.

A wait-and-see opportunity

Yet the AFA decision to postpone any strike activity had an immediate practical impact. U.S. Bankruptcy Judge Allan Gropper has not issued a ruling concerning Northwest's motion to block a strike by attendants. With the new strike deadline an extra 10 days away, Gropper can wait to see whether the two sides can get back together again.

"We are open to meeting with the AFA to reach a consensual agreement that meets the $195 million [annual] labor savings target for the flight attendants," airline spokesman Bill Mellon said Monday.

Because Northwest is adhering to that concessionary target, Campbell said, "There is not a lot of maneuvering that we can do."

Although talks have not been restarted, Campbell said the two sides met face-to-face Monday afternoon in Bloomington.

The AFA was elected in early July to represent Northwest attendants, so the purpose of the session with airline management was to discuss several administrative matters, Campbell said.

Northwest has ratified agreements with five of its seven unions. The carrier set work terms for flight attendants July 31, while replacement mechanics have been working under imposed pay rates and work rules since last August. Today, Northwest has its first bargaining session of the year scheduled with the Aircraft Mechanics Fraternal Association.

Outsourcing at small stations

The airline's largest union, the International Association of Machinists and Aerospace Workers (IAM), ratified an agreement that allows Northwest to hire outside companies to do work at the stations that have the smallest number of flights.

Northwest's Blahoski said that 69 stations will be affected by the transition to outside contractors. Northwest employees in those cities are expected to use their seniority to transfer to the airline's larger locations, resign, retire or seek employment with the new vendors.

In addition to contracting with Mesaba and Pinnacle for some of the ground handling work, Blahoski said Northwest also plans to use a number of other vendors. He cited Swissport, a large company that does some Northwest maintenance work; regional carrier Air Wisconsin; Worldwide Flight Services; and Airport Terminal Services.

Northwest has begun to circulate a 161-page ground operations restructuring manual for employees but has received some worker criticism about two pages that included 101 ways to save money.

Blahoski said that part of the manual contained suggestions from an outside company. "We agree that some of that material was insensitive," he said, so it will be removed from future manuals. The early version of the manual, which explains retirement benefits, severance payments and bidding rules, was distributed to about 50 employees, mainly at North Dakota stations, he said.

According to the IAM contract, Northwest is prohibited from outsourcing ground handling work at stations that had 50 or more passenger departures a week on the 2005 schedules.

Liz Fedor - 612-673-7709

Monday, March 5, 2012

Schiedea Lydgatei

Schiedea lydgatei

No Common Name

Status Endangered
Listed October 8, 1992
Family Caryophyllaceae (Pink)
Description Low growing perennial with stems that are branched and woody at the base.
Habitat Ridges and cattle trails in dry to mesic …

Maternity unit granted summer reprieve.

EXPECTANT mums can breathe a sigh of relief as maternity services in Eastbourne and Hastings have been given a last-minute reprieve.

NHS chiefs have decided to keep the unit running at the DGH beyond August 1, when it was widely expected it would close as a 'temporary measure'.

The announcement was made this week by East Sussex Downs and Weald Primary Care Trust (PCT), the organisation responsible for funding hospital services.

But campaigners are urging people to carry on fighting to keep the DGH intact.

Liz Walke, chairman of Save the DGH, told councillors the news at a council meeting on Wednesday.

She said, "There will be no …

ALBANY MAN ADMITS STABBING EX-GIRLFRIEND.(CAPITAL REGION)

Byline: TRACEY TULLEY Staff writer

When William Langton pleaded guilty on Wednesday to stabbing his former girlfriend, it wasn't to avoid the damning testimony of a victim who might turn the court against him.

The woman has said she still loves Langton. She wants the court to dismiss the order of protection she sought after he first tried to rape her.

The plea Wednesday was based on a growing determination to prosecute abusers with or without the help of their victims, Assistant District Attorney Veronica Dumas said. In this case, the prosecution felt its evidence was strong.

``We are willing to prosecute without the victim,'' Dumas said. …

Today in History - Jan. 4

Today is Monday, Jan. 4, the fourth day of 2010. There are 361 days left in the year.

Today's Highlight in History:

On Jan. 4, 1960, Algerian-born French author and philosopher Albert Camus died in an automobile accident in Villeblevin, France at age 46.

On this date:

In 1809, Louis Braille, inventor of the Braille raised-dot reading system for the blind, was born in Coupvray, France.

In 1821, the first native-born American saint, Elizabeth Ann Seton, died in Emmitsburg, Md.

In 1896, Utah was admitted as the 45th state.

In 1904, the U.S. Supreme Court, in Gonzalez v. Williams, ruled that Puerto Ricans …

A look into his 'Germany'

With a new memoir out, gay author Lev Raphael explores his past and connects it to the LGBT movement

Lev Raphael is standing in the doorway of his home, holding back one of his West Highland Terriers. Promptly he is in the kitchen, using his Braun coffee maker, an emblem of a fear of all things German his new book, "My Germany," has helped him to overcome.

For nearly two decades, Lev Raphael has mined the landscape of his youth as a "second generation" of Holocaust survivors. But in his newly released My Germany, the focus of his work turns towards understand, truth and history.

"My Germany," Raphael's recently released memoir, explores not only the war time …